Some victims die from ventricular fibrillation, which can result from acute coronary ischemic thrombosis in an otherwise normal heart, 7-9 whereas others die from tachyarrhythmias arising from chronic scar. Ventricular tachyarrhythmias are responsible for most cases of sudden cardiac death, although there is more than one mechanism for these arrhythmias. Because so many instances of sudden cardiac death cannot be predicted, any intervention directed toward the general community would have to be applied to an estimated 1000 persons for every 1 person in whom sudden death might be prevented. 1,5 Advanced therapies such as thrombolytic agents and implantable cardioverter/defibrillators are of no value to the thousands of victims who do not survive to receive medical attention. 1-4 Although in some subjects there is a history of angina pectoris, myocardial infarction, or previous cardiac arrest, a significant proportion of events occur in subjects without any history of cardiac disease. Sudden cardiac death accounts for ≈50% of the estimated 500 000 cardiovascular deaths that occur annually in the United States, and a vast majority are the result of coronary artery disease. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.

Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).

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